I have two female spayed lionheads. I live in VA and South FL. I drive between the two places with 3 cats, 2 rabbits, and a hamster in a Van. The drive is 12-13 hrs depending on stops and traffic. The rabbits have a large travel cage with a shelf. I line the bottom of the cage with piddle pads then fleece over the piddle pads. I put in a hay trough, a bowl for pellets, and a no drip water bottle. I add a little pillow/mat for the shelf. In the van, I bungee the cage so it doesn’t move around and then cover it with a blanket leaving one end exposed so they can see a little and get fresh air. The bunnies usually sleep most of the trip.
As for a hotel, I use an ex-pen and ALWAYS bring their litterbox they use at home. Bring toys and blankets they are familiar with. It is important to make sure they can not get out. A top to the ex-pen would be ideal.
Good luck!