This is when they do start to nibble on hay and then will gradually start trying out their mom's food and water once they are able to crawl out of their nest. At this point you'll want to clean out the next box if you haven't already, and try and save as much of the clean and dry bedding and fur as possible. Then either remake the nest if they aren't trying to crawl out yet, or if they are consistently trying to get out, I would either make sure they have a step to be able to get in and out, or turn the nest box on it's side and put a layer of hay on the bottom of them to snuggle up in. Also all of their eyes should be open by 14 days.
You'lll have to wait until the babies are completely weaned before you can get her spayed. So in about 4-6 weeks, depending on if she decides herself to wean them early, but if she doesn't then it's preferable to keep the with mom until at least 8 weeks old and start weaning them around 7-8 weeks old.