PS: It really sounds like it could beMycotoxin poisoning. Here's a few of the relevantexcerpts from the above link.
2. What are the symptoms of mycotoxin poisoning (mycotoxicosis)?
[align=justify]The symptoms are wide-ranging and similar to more well-known ailments. Mycotoxins may cause:[/align]
- Gastrointestinal problems (slowdown, delayed stomach emptying, stasis/colic, hemorrhages of the large intestine, shock, reduced gastric and small intestine flow, necrosis of the GI tract, severe bloating, impaction, shutdown without blockage, refusal to eat, weight loss, increased water consumption, vomiting, enteritis).
3. How can mycotoxin poisoning be diagnosed?
The poisoning may manifest as on-and-off, chronic or acute episodes, depending on the amount of toxic feed ingested and how consistently it was fed. The damage to internal organs is cumulative over a period of time. A high incidence of gastrointestinal upsets (impactions, etc.) and of disease associated with depressed immune function (Pasteurella, etc.) may be clues that a mycotoxin problem exists. Some clinical signs which may appear in a rabbit:
- Severe pain in the abdomen -- sudden onset, haunches flaring out, belly pressed against or writhing on the floor, bunny might be lethargic and hide in a corner.
- A radiograph (x-ray) series may reveal gut shutdown but no physical blockage (barium barely drips through), sometimes severe bloating. Often diagnosed as GI stasis or stenosis without identifying the underlying cause.
- Standard GI stasis treatments no longer work, GI motility drugs (Cisaspride/Metachlopromide) lose their effectiveness either because the tissue along the GI tract is necrotic/damaged or because of the overwhelming deoxynivalenol(DON)-induced inhibition of gastric emptying via serotonin receptor sites.
- Hypothermia (low body temperature).
- Blood abnormalities: high BUN and creatinine levels, calcium-phosphorus imbalance (which may lead to chalky urine, organ calcification), abnormal levels of liver enzymes associated with kidney/liver failure; low hematocrit/RBC due to internal bleeding.
- Ulcers in the mouth (strange chewing and tongue motion, difficulty swallowing, teeth problems ruled out), stomach and esophagus.
- Refusal to eat, weight loss.
- Presence of mucous in the feces.
- Rough hair coats.
- Sometimes paralysis or twitching in hind limbs.
- Multiple bunnies fall ill simultaneously in the same household.
- Food tests positive for mycotoxins.
- An endoscopic examination may reveal ulceration along the GI tract but this procedure is difficult to do on small animals.
- Necropsies may show: GI bruising (often subtle), hemorrhages, stomach/GI ulcerations, mouth ulcers, kidney/liver damage (lesions, lipidosis, fibrosis, swelling, discoloration), rectal prolapse.
While many mycotoxins can be measured in environmental samples, it is not yet possible to measure mycotoxins in human or animal tissues.
4. What is the treatment for mycotoxin poisoning?
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Sucralfate: Break one-gram tablets of Carafate (sucralfate) into quarters. Administer 1/4 tablet orally every 8-12 hours mixed with water. Drop the 1/4 tablet into a feeding syringe, hold your finger over the tip, add some water, shake it well until it is dissolved, then invert the syringe and bleed off the excess air before syringe feeding (from the side of the mouth, in the gap behind the front teeth). Ideally, it should be given on an empty stomach (one-two hours before meals). Sucralfate should be staggered 3-6 hours apart from other medications because it tends to bind with other drugs (including cimetidine = Tagamet), reducing their absorption and effectiveness. Although healing begins within one to two weeks, it should be administered for at least 3-4 weeks (sometimes up to 8 weeks) to make sure healing is complete. Do not miss a dose because it works cumulatively.
Sucralfate is a "cytoprotective" agent that binds to the ulcerated erosion sites to form a protective barrier and promote healing. This prevents bacteria from crossing through the damaged tissue along the lining in the GI tract and entering the bloodstream, which may cause septicemia (blood poisoning). It is a very safe and effective drug.
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Antibiotics (injectable Penicillin G) to guard against bacterial infection and septicemia/toxemia.
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Subcutaneous fluids (in mild cases) or IV fluids (in severe cases) to flush out the toxins. Treat for renal failure with supportive therapy.
[*]If severe bloating occurs, the stomach might need to be pumped (carefully) to prevent it from rupturing.
[*]Ask your vet whether other anti-ulcer drugs might be helpful.
Prilosec (omeprazole), which suppresses the acid "proton pump" in the gastric mucosa, has proven very effective in treating ulcers in horses (the closest physiological model to a rabbit; both are single-stomached hindgut fermenters).
Zantac (Ranitidine HCl), which reduces the production of stomach acid by inhibiting histamine, is much more effective than
Tagamet (cimetidine).
[*]Note: Bunnies may have sensitive GI tracts for awhile. Fluids and sucralfate should be re-administered at any sign of discomfort during the following months.