Does he seem uncomfortable? Is he pressing his stomach to the floor or anything like that? Will he take a treat?
Do you know for sure the gurggling is abnormal for him? Just gurgling alone doesn't indicate gas.
There are certain drugs that simethicone should not be taken in conjunction with, and I believe an antibiotic may be on that list, but I can't recall any names.
Best to not treat unless you're sure he needs it and you're sure he can take it.
I'll look for more info, but our search function still isn't working, might take awhile!
sas :?