Check around the site and read some of the other threads on grumpy rabbits. I think a lot of them are just bored out of their little bunny minds, hate captivity, and therefore see little reason to love their captors. You did not say how much space she has, what her living quarters are like, etc., but certainly if she is in a hutch, do whatever you can to give her more space, and try to give her something to do with her time. There have been some interesting posts on how to provide rabbits with digging opportunities, etc.