Looking for information on genetic problems that can cause death

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TinysMom

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For those of you who do not know - Dusty, Drew and Bun Bun were all lionhead littermates that were born on February 15, 2007. When their sister Lily moved on to live with another forum member - they stayed here because they were going to be flying to Calfiornia last September. However, the way things worked out - they wound up staying longer.

The only thing that was unusual about their early days was that frequently Drew would have a damp nose. She was the smallest bunny and obviously carried the dwarfing gene (but she was NOT a peanut). If she got stressed or if she played in the litter box (one of her favorite pasttimes) - her nose would be damp for a couple of days.

Their father has fathered many MANY litters before coming to live here in 2006 and he fathered other litters here also. Their mama had one other litter before I had them - no problems (that I know of) with the offspring. However, their father passed away suddenly last July - I have no idea why. He had not been ill - but I went out to his cage and he was gone - and he was 2 years old. Sometimes that just happens...even to younger rabbits. I now wonder if somehow the mother and the father each carried some sort of a gene that when brought together - would cause problems.

On the 21st of October, Drew passed away. She'd had a minor bout of stasis earlier in the week - but by the time she passed - she was eating and pooping and peeing and drinking. I really can't say so much she had stasis as to my knowledge her gut never shut down - she just didn't eat as much.... However, she was still eating and binkying and in fact, earlier in the week I'd had to ask her to be just a bit quieter while I was on the phone (she lived in my office and was doing her bunny 500s and binkying).

On December 17th - less than 2 months later - Bun Bun passed away. He was the biggest of the three and his passing was very sudden also. We suspected heart problems or a genetic issue like with Drew because one minute he was fine - and a couple of hours later - he was gone.

Now - at that time - I discussed with some folks I trust the idea of getting a necropsy done on Bun Bun -or possibly taking Dusty in for testing. Dusty was about Drew's size - still sort of small (but not "badly" small like a peanut - he was more like a Netherland Dwarf size vs. a normal lionhead size. Their mama is a smaller lionhead too). We tried to decide if a necropsy would show up the cause of death if it was a genetic issue...or would it be best to take Dusty in for an Xray and/or ultrasound.

The decision was made to just keep an eye on Dusty - to keep him here and not have him fly to Rosie...and to possibly have him checked in a month or so. It did not appear to be an immediate need as he was eating and drinking well and pooping and all of that.

Last night - we suddenly lost Dusty. Once again - no warning except to see him struggling for breath. I noticed his heart was pounding pretty darn hard. From the moment we first knew he was in distress - till he was gone - was 2 hours. (The closest emergency vet is a minimum of a 3 hour drive in daylight).

I've been thinking about this and trying to come up with what has been happening - what could have caused this. There is still one more in the litter that is alive - that is myLoki's darling Lily. My hope and prayer is that whatever took these three will not affect her.

Some of the things I've discussed with others are:

  • Other deaths I've had in the rabbitry (not related at all to these animals nor in the same area of the house/rabbitry)
  • locations of their cages, etc. when they died (Drew was in my office - the other two lived in my living room)
  • and much much more.
The only thing I can come up with is this...

Although each rabbit (especially after Drew's passing) was held and petted several times per week - they seemed to lose a bit of weight within the last 2-3 days before they passed away. Each time I would hold one - I would make the comment "You seem to have lost a bit of weight". Now when I say this - I'm talking about 2 - 3 or maybe even 4 ounces on a 3 pound rabbit.

Usually - the rabbits had gone off their food by about 25-33% for the last 3 or 4 days of their lives. Because each death happened around the time we were having weather changes....when many of my rabbits might not eat as much - I did not pick up on this fact until last night when we were with Dusty and comforting him as he prepared to cross the bridge. It is not unusual for my rabbits to not eat as much food for up to 4 days and then suddenly start scarfing everything down. They did have poops and pee during that period of time.

None of the other rabbits I've lost have shown these symptoms (that I know of)....except for losing the father in July. None of the other rabbits have appeared ill (as far as thinking maybe it was something in the food or the hay).

In each case - the rabbit was fine - and then was dead within a couple of hours. No nose discharge except maybe a dampness on the nose for Drew....I don't remember about Bun Bun.

None of the rabbits appeared to be in "pain" as far as having blockages, straining to pee, etc. etc. etc. The first sign of distress was having them breathe with their mouth open and holding their noses in the air.

In each case - I had seen the rabbit play within the last 24 hours...and it had appeared normal.

That is all I can think of to share here. I'm hoping that maybe someone from here will have read something about genetic issues that can occur or will know of more information we can use to find out what has been happening.

Thanks for taking the time to read this.

Peg



 
This is great info for me, thanks Peg, I know some things to watch for. :hug1

I have a vested interest in thiswith my foster family, we've lost three or four of a year-oldlitter of eight, including little Jordan last week. The necropsies showed liver and kidney cancer for his sibblings, inconclusive for Jordan, althoughhis liver was bad. (Jordan had a long vet stay and x-rays a month or two before he died, they didn't pick up anything, I don't think he had a blood test though).

At least one of Peg's bunnyseemed to show symptoms closer to heart problems, I think. I know that blood tests will weed out kidney and liver issues, but I'm not sure about heart issues. What would an xray show? Would it pick up congestive heart failure? The liquid around the sac (or whatever).

What about an ultrasound? That will show the heart in motion, but how necessary would that be? And does a bunny need to be sedated to have one? If so, itmay make the question of a pre-surgery check upsomewhat of amoot point.

Any input on this would be most welcome.


sas :bunnydance:


 
peg, I've been looking around for information since you lost Dusty. A lot of what I find is stuff you have to have memberships to get into and such. What I did find is that there are a few genetic things that can of course occur, but this is what I am thinking: Thymoma

Here's a bit of info from a website - it's kinda interesting.

http://www.afip.org/vetpath/POLA/99/PATHOLOGY_OF_THE_RABBIT-Wilber.htm

. NEOPLASMS

A. Uterine Adenocarcinoma

Uterine adenocarcinoma is the most common spontaneous neoplasm of the rabbit. The incidence increases with age and nearly all breeds are affected. The role of estrogens in development of this neoplasm is equivocal. Grossly, there are multiple, nodular thickenings that protrude into the uterine lumen. Histologically, these thickenings are composed of acinar and tubular structures supported by a vascular myxoid stroma. There is serosal implantation and metastasis most commonly to the lung and liver.

B. Lymphosarcoma

Lymphosarcoma is seen most commonly in juvenile and young adult rabbits and is typically the visceral form involving the liver, spleen and kidney. Occasionally, leukemia is present. At necropsy, there is lymphadenopathy, splenomegaly and hepatomegaly with multiple, white circumscribed nodules. Histologically, the cells are usually of the lymphoblastic type.

C. Pituitary Adenoma

Prolactin secreting pituitary adenomas in aged New Zealand White rabbits cause mammary gland dysplasia. Histologically, the glands have cystic areas lined by reactive epithelial cells with papillary projections extending into the cystic lumina. Blood prolactin levels can be measured and will be elevated.

D. Thymoma

Thymomas occur in rabbits at a low incidence and are usually diagnosed at necropsy. Clinically, they cause coughing, tachypnea, dyspnea and exercise intolerance. Thymomas have been associated with paraneoplastic syndromes such as myasthenia gravis, autoimmune disease and hypercalcemia of malignancy, etc. There is a report of a successful surgical removal of a thymoma in a rabbit.

E. Transplantable Neoplasms

There are a few transplantable neoplasms that have been studied in rabbits and these include Vx2 carcinoma, Brown-Pearce carcinoma, Greene melanoma, Dos Santos hepatoma, Kato sarcoma, Andrewes rabbit sarcoma I and Kondrateva osteogenic sarcoma.

F. Other Neoplasms

Several other neoplasms occur spontaneously in the rabbit and include fibroma, squamous cell carcinoma, teratoma, renal carcinoma, nephroblastoma, leiomyoma and leiomyosarcoma, mammary gland adenoma and adenocarcinoma, osteosarcoma, hemangioma and hemangiosarcoma, fibroma and trichoblastoma. Interstitial tumors are probably the most common neoplasm of the testes in rabbits.

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Ivory may be able to ask her dad and my niece is in vet school now. I will see her sometime soon and I'll see if she can look into some text books for me or something.... [/b]



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I think that a necropsy could answer a lot of your questions Peg.

Thymomas are rather rare in rabbits and generally don't occur in younger rabbits. Thymomas can be diagnosed during a necropsy.

I'm leaning more towards a heart or artery defect. These types of inherited diseases are rather common in rabbits.


Pam
 
pam, I think that is possible too but that kept coming up.

Did I mention (i forget lol) that I had an enlarged thymus at birth?
 
Bo B Bunny wrote:
pam, I think that is possible too but that kept coming up.

Did I mention (i forget lol) that I had an enlarged thymus at birth?

Very interesting!

Peg, I hope you'll be able to get a necropsy done and let us know what the vet comes up with.

Pam
 

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