i answered, once a day because they have the coroplast bottom so i dont technicall have to really clean it. I dump there litter boxes everyday, and clean it with vinegar about every other to every 2 days, but there is no need to really clean the bottom of there cage because they go in there boxes. I do vacuum the bottom of the cage for stray poop, and hair everyday, and then if necessary i will wipe out the bottom of the cage with a baby wipe or something.