Rabbits don't generally like to be 'picked up'. They like all four on the floor.
Is it a young rabbit?
They do get use to being handled,so don't fret just yet. You just need patience in letting them get use to it, and you.
I have adopted older rabbits who were terribly abused, and they understandable seemed scared when being picked up.
But, I have managed to win them all over. In some cases it took months, but they all 'got over it'!
It's essential that you are able to pick them up and handle them - tocheck them physically for problems, to clip their nails, look in theirears, and look at those teeth!
You have to hold them securely, supporting their bum, and hold themagainst your body. If they feel like you will let them fall, they willpanic and frail about - and may bite you as a fearful reaction.
Good luck, and keep us posted!